Breakthrough Therapies for Metastatic & Primary Cancers

Our multi-patented, ZetaMet™ (Zeta-BC-003) therapy is a first-of-its kind molecular pathway designed to suspend cancer, inhibit pain, and regenerate bone with the potential to increase survival rates.

Latest Updates

Publications & Press Releases

Zetagen Therapeutics Closes Oversubscribed Series B1 Round on Strength of Promising Phase 2a Data and Compelling Pipeline 

November 25, 2025, (Syracuse, New York) — Zetagen Therapeutics, Inc., a privately held, clinical-stage biopharmaceutical company pioneering first-of-its-kind, intratumoral treatments for metastatic and primary breast cancer, today announced the successful closure of its Series B1 financing round of $12,908,000. The round was 100% oversubscribed, reflecting strong investor confidence in the company’s proprietary Zeta Platform and its potential to transform breast cancer care.

Zetagen Therapeutics to Present Preliminary Results from Phase 2 Clinical Trial Targeting Metastatic Breast Cancer to Bone at the 2025 San Antonio Breast Cancer Symposium

November 4, 2025, (Syracuse, New York) — Zetagen Therapeutics, a privately held clinical-stage biopharmaceutical company pioneering first-of-its-kind targeted therapies for both primary and metastatic breast cancer, announced today that its abstract titled “Single Intratumoral Drug Injection Yields Complete Response (CR) in Metastatic Breast Cancer (MBC) Bone Lesions”, has been accepted and will be presented at the 2025 San Antonio Breast Cancer Symposium (SABCS) on Wednesday, December 10, 2025.

Zetagen Therapeutics to Present Promising Preclinical Data at SABCS: Zeta-BC-007 Demonstrates Superior Tumoricidal Activity and Survival Benefit in Breast Cancer Model

November 4, 2025, (Syracuse, New York) — Zetagen Therapeutics, a privately held clinical-stage biopharmaceutical company pioneering first-of-its-kind targeted therapies for both primary and metastatic breast cancer, announced today that its abstract titled “Increased Survival in Nude Mice Inoculated with MCF7 Breast Cancer (BC) in the Mammary Fat-Pad Achieved via a Single Injection of a Lipid-like Hydrogel Emulsion Containing a New Molecular Entity (NME) and N-ally Noroxymorphone (NaN) Compared to Tamoxifen (TAM) and Abemaciclib (ABE)”, has been accepted and will be presented at the 2025 San Antonio Breast Cancer Symposium (SABCS) on Thursday, December 11, 2025.
What we do
For Our
Patients
Zetagen is focused on the 330,000 people in the United States and more globally, annually living with some form of bone metastases. We have created a series of novel therapies which address metastatic cancers at progressive stages. Our therapies are designed to suspend cancer, inhibit pain, and regenerate bone with the potential of increasing survival rates. These novel drugs from Zetagen are adjunctive to other cancer treatments and can be locally administered, to bone or soft tissue organs, when the lesion is first detected via a brief out-patient procedure. Pre-clinical studies and peer-review published data have shown the potential to reduce lesion size by 200% and in some cases completely resolve, reduce pain by 400+%, and improve mortality rates of 250%.
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0
k
Patients Annually Diagnosed with Breast Cancer
(1 out of 8 Women)
0
k
Patients Annually Diagnosed with Metastatic Lytic Bone Lesions
(Breast, Lung, Myeloma, and Prostate)
0
%
% of patients Develop Skeletal-Related Event (SRE) from Metastatic Lytic Bone Lesions
*References: Australia (nbcf.org.au) | Canada (cancer.ca) | USA (breastcancer.org, ncbi.nlm.nih.gov, sciencedirect.com)
Breakthrough Technology

For Metastatic Therapies

The U.S Food and Drug Administration (FDA) has recognized Zetagen’s discoveries with multiple Breakthrough Designations. Zetagen discovered and patented the first-of-its kind molecular pathway designed to suspend cancer, inhibit pain, and regenerate bone. The small molecule has been approved by the FDA since 1971. Our research scientists have discovered an entirely new pathway for this established molecule which, if proven successful in human clinical trials, could create a new treatment paradigm for patients living with metastatic bone lesions and other osteologic conditions.
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