Through Zetagen’s novel discovery, ancillary specialties will benefit from this discovery, such as Musculoskeletal fusion procedures.

Zetagen offers a complete line of therapies to address osteoporotic fractures, extremity trauma, and spinal fusion. The annual U.S. statistics for these indications are:
850,000 inpatient hospitalizations annually due to bone fracture
630,000 bone fractures procedures in high-risk populations
450,000 lumbar and 150,000 cervical spinal fusion procedures performed


ZetaFuse™ is the first synthetic, small molecule, osteo-inductive biologic, to safely aid bone healing of spinal fusions. The U.S. Food and Drug Administration (FDA) has awarded ZetaFuse™ Breakthrough Device Designation[1] for the complete spinal column. 

ZetaFuse™ is driven by the activation of a novel molecular pathway, by leveraging this patented mechanism, to directly turn stem cells into osteoblasts (osteoinductive) and prevents bone resorption (anti-osteolytic).
ZetaSet™ is the first synthetic, osteo-inductive, biologic designed specifically for the treatment of osteoporotic fractures, high energy injuries with bone defects, and for patients with fractures of the tibial plateau (knee) and plafond (ankle).

The advantage for patients is that ZetaSet™ allows the broken or collapsed vertebral body to remodel and heal itself (osteogenesis) while providing the structural support needed for immediate relief.

Currently, doctors have the option of using bone cement, polymethylmethacrylate (PMMA), to treat vertebral fractures. Some studies have shown long term results with PMMA may become a stress riser. Thus, ZetaSet™ would be the first osteo-inductive biologic to aid in the patient growing their own bone with like kind modulus of elasticity (strength & flexibility).

A vertebroplasty procedure is a way to treat vertebral body compression fractures, which are small breaks in the thick mass of bone that make up the front part of the spinal column “the vertebral body”. Vertebral body fractures lead to the collapse or compression of a vertebrae, causing the spine to shorten and curve forward, and result in pain and kyphosis (hunched over deformity). Thinning of bone, or osteoporosis is the main cause of vertebral compression fractures. 




ZetaBase® is an osteo-conductive and osteo-promotive therapy and is intended for the use as a bone void filler for bony voids or gaps that are not intrinsic to the stability of the bony structure.  ZetaBase® Bone Graft can be used as a bone graft extender.

The ZetaBase® Bone Graft is a moldable, cohesive, putty that can be pressed into surgically created osseous defects or osseous defects created from traumatic injury to the bone.

ZetaBase® Bone Graft is available in various sizes and is provided sterile, non-pyrogenic, and for single use only.